In 1956, Dr. Robert Galbraith Heath, Chair of Psychiatry and Neurology at Tulane University School of Medicine in New Orleans, announced that he and colleagues had discovered a protein they called taraxein in the blood of schizophrenic patients that caused symptoms of schizophrenia when injected into healthy volunteers. Heath's claim received wide public and professional attention. Researchers quickly tried to confirm the discovery. These efforts, which were rigorous and in some cases conducted in consultation with the Tulane researchers, failed. Nevertheless, for the next four decades Heath continued to defend his claim. This article recounts the scientific dev elopments that led up to Heath's putative discovery and it explores the scientific findings for and against the taraxein theory of schizophrenia.
W 1956r. ogłoszono odkrycie proteiny we krwi schizofreników nazwanej "taraxein", która wywoływała objawy schizofrenii u zdrowych ochotników po iniekcji.
https://en.wikipedia.org/wiki/Taraxein - jednak wszystkie próby potwierdzenia tej hipotezy nie powiodły się.
“Experimental studies on taraxein and LSD.”. Acta psychiat.Scandinav.. 1959;34:Suppl. 136, 344. https://www.erowid.org/references/refs_view.php?ID=1842
Taraxein (an amount corresponding to 400 ml. or serum) given i.v. to Rhesus monkeys causes behavioral changes dominated by catatonic-like phenomena. . When 2-3 mg/kg body weight Kabi 888 (di-iso=propanol-aminopropyl-phenothiazine-HC1) was given i.v. at the height of the taraxein effect (i.e. 15 minutes after the taraxein i.v.) complete loss of muscle tone, general piloerection and a deep sleep followed immediately. The animal could not be aroused for 10-15 minutes and then returned to "taraxein behavior". The above-mentioned dose of Kabi 888 alone did not have any effect. . 15-30 mcg/kg LSD was given i.v. to the same monkeys. They becamse slightly "catatonic" but the reaction was weaker than with taraxein. At this stage and i.v. injection of 2-3 mg/kg Kabi 888 produced a loss of muscle tone followed by a deep sleep-like state (10 minutes long). . 0.1-1 mg/kg acetylcholine, adrenalin, adrenolutin, atropine, histamine, mescaline and serotonin when given i.v. to cats produced no marked change of behavior. Following premedication with LSD the same amounts of the above-mentioned drugs caused striking behavioral changes. . The authors presume that LSD and taraxein enable certain i.v. injected drugs to act upon brain structures which are normally not accessible to them. . Preliminary studies with acetyl-LSD (ALD) and BOL-148 (dosage as LSD) showed that ALD but not BOL- 148 had an LSD-like effect.
Taraxein podany małpom powodował u nich katatonię i inne zmiany...